The establishment of the Capuchin Mission in Deir ez-Zor dates back to the early 20th century, with the Latin Catholic Church known as the Capuchin being one of the oldest churches in Deir ez-Zor. Its current structure was built in 1930. The church includes a monastery and a home for the elderly named after Mother Teresa.
The Capuchins focused on providing humanitarian and educational services alongside religious activities, founding a school and library affiliated with the church, which significantly contributed to improving education among local residents regardless of religious affiliation.
The church features a simple design reflecting Franciscan monasticism, incorporating elements that embody an Eastern character, such as small domes and ornate windows. It was destroyed by gangs affiliated with the former regime, who sought to erase cultural and religious identities; however, it holds a special place in the hearts of both Christian and Muslim residents of the province.